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New Linker for Solid-Phase Organic Synthesis and Drug-Screening Libraries
These compounds offer excellent stability over an unprecedented array of reaction conditions for use as protecting groups or linkers between solid substrates and reactant compounds.At a GlanceUseful for complex syntheses, generation of drug-screening libraries, as a protecting groupBinds target molecules with carboxylic acid, amine, alcohol, or phenol...
Published: 11/8/2018
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Inventor(s): Michio Kurosu, Dean Crick
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials
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A Metal Reducing Enzymatic Tag for Optical and Electron Microscopy
At a Glance: ● A clonable maker for electron and optical microscopy. ● Allows for high resolution imaging using non-disruptive modalities● Can be readily adapted to flow cytometry● Potential to provide a platform for radio frequency interactions with a protein of interest.● Immediately applicable markets: academic research,...
Published: 11/8/2018
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Inventor(s): Christopher Ackerson, Zachary Butz, Richard Nemeth, Ryan Riskowski, Kanda Borgognoni
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Electronic Devices & Instrumentation
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Method and Apparatus for Generation of Traveling Waves in High-Field and Ultra-High-Field MRI Systems Using Bore-Extended, Subject-Loaded Helical Antennas
Summary:The main area of engineering research in advancing next-generation MRI scanners at high (B0=3T) and ultra-high (B0 > 3 T) polarizing fields is in improving RF coils and RF magnetic fields (B1) in an MRI bore loaded with a human body or a phantom. This invention features a new RF coil, the subject-loaded multi-channel helical-antenna RF...
Published: 11/8/2018
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Inventor(s): Branislav Notaros, Milan Ilic, Alexey Tonyushkin, Nada Sekeljic, Pranav Athalye
Keywords(s):
Category(s): Biotechnology, Electronic Devices & Instrumentation
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Design of a Dynamic Stabilization Device for the Correction of the Center of Rotation in the Lumbar Spine
Inventors: Christian Puttlitz and Ben GadomskiPatent status – US and PCT patents pendingBackgroundDespite the relatively large number of dynamic stabilization designs that have been proposed, an implant designed to manipulate the motion segment’s center of rotation (COR) has not been developed. A successful implant must restore natural...
Published: 11/8/2018
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Inventor(s): Christian Puttlitz, Benjamin Gadomski
Keywords(s):
Category(s): Biotechnology, Human Health
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Split-Supercharged GFP: A Robust Platform to Detect Protein-Protein Interactions
Patent Status: US Patent Issued, PCT Patent PendingFeatures and Benefits• Rapid detection of polypeptide interactions inside E. coli• High signal-to-noise• Efficient peptide-peptide interaction detection at physiological temperature• Detection of interactions involving aggregation-prone polypeptides Split-supercharged...
Published: 11/8/2018
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Inventor(s): Brian McNaughton, Brett Blakeley, Alex Chapman
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Category(s): Biotechnology, Chemicals & Materials, Other Innovations
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Multifunctional Phage as Targeted Delivery Platforms for Therapies and Imaging Reagents
Phage that potently and selectively delivery various cargo to cancer cells, with application to many human and other mammalian cancers.Innovation DetailsEvery strategy to identify and combat disease can be improved by selective delivery of cargo specifically to diseased cells. Small molecules and nanoparticles have been used to target many diseases...
Published: 11/8/2018
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Inventor(s): Brian McNaughton, Sandra DePorter, Irene Lui
Keywords(s):
Category(s): Biotechnology, Human Health, Chemicals & Materials
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Growth Factor Stabilization and Delivery for Biomedical Devices and Orthopaedic Implants using Polysaccharide Based Multifunctional Coatings
Inventors: Matt Kipper, Ketul Popat and Melissa Reynolds, Victoria Leszczak, Raimundo RomeroPatent status: US and PCT patents pendingThis invention is a method for modifying the surfaces of vascular stents and orthopedic devices to introduce multiple biological functions to the surface. Its use can be extended to other blood contacting devices (e.g....
Published: 11/8/2018
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Inventor(s): Matthew Kipper, Ketul Popat, Melissa Reynolds
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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HeX-Bond for molecular engineering, medicinal chemistry applications, materials chemistry, and biological or chemical engineering
Investigators at Colorado State University have discovered a new form of a non-covalent interaction, which is named a hydrogen bond enhanced halogen bond (or HeX-B, for short). The HeX-B was engineered into the enzyme lysozyme to increase the thermal stability of a commonly used enzyme by 1°C and the activity by 15% at elevated temperatures relative...
Published: 11/8/2018
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Inventor(s): Pui Shing Ho, Anna-Carin Carlsson, Matthew Scholfield, Melissa Ford, Rhianon Rowe, Austin Alexander, Ryan Mehl
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Nanobody conjugates and protein fusions as bioanalytical reagents
In many bioanalytical techniques, antibodies are essential for performing a technique. These antibodies recognize a particular protein (known as an epitope) and are often linked/conjugated to proteins or dyes to allow visualization (known as reporters). The size and complexity of traditional antibodies and the reporter conjugates complicates their...
Published: 11/8/2018
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Inventor(s): Brian McNaughton, Virginia (Ginny) Bruce
Keywords(s):
Category(s): Biotechnology
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High Speed, Large Volume and High Field of View 3D Fluorescent Optical Imaging Instrument
Several related optical technologies that enable rapid, 3D imaging of highly scattering tissues with a variety of techniques that utilize non-coherent contrast signals, such as fluorescence-based emission.At a GlanceOptical imaging platform technology for rapid 3D imaging even for highly scattering tissues.Does not require coherent light signal, suitable...
Published: 11/8/2018
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Inventor(s): Randy Bartels, Jeffrey Field, David Winters
Keywords(s):
Category(s): Electronic Devices & Instrumentation, Biotechnology
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