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Design of a Dynamic Stabilization Device for the Correction of the Center of Rotation in the Lumbar Spine
Inventors: Christian Puttlitz and Ben GadomskiPatent status – US and PCT patents pendingBackgroundDespite the relatively large number of dynamic stabilization designs that have been proposed, an implant designed to manipulate the motion segment’s center of rotation (COR) has not been developed. A successful implant must restore natural...
Published: 11/8/2018
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Inventor(s): Christian Puttlitz, Benjamin Gadomski
Keywords(s):
Category(s): Biotechnology, Human Health
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Multifunctional Phage as Targeted Delivery Platforms for Therapies and Imaging Reagents
Phage that potently and selectively delivery various cargo to cancer cells, with application to many human and other mammalian cancers.Innovation DetailsEvery strategy to identify and combat disease can be improved by selective delivery of cargo specifically to diseased cells. Small molecules and nanoparticles have been used to target many diseases...
Published: 11/8/2018
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Inventor(s): Brian McNaughton, Sandra DePorter, Irene Lui
Keywords(s):
Category(s): Biotechnology, Human Health, Chemicals & Materials
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Growth Factor Stabilization and Delivery for Biomedical Devices and Orthopaedic Implants using Polysaccharide Based Multifunctional Coatings
Inventors: Matt Kipper, Ketul Popat and Melissa Reynolds, Victoria Leszczak, Raimundo RomeroPatent status: US and PCT patents pendingThis invention is a method for modifying the surfaces of vascular stents and orthopedic devices to introduce multiple biological functions to the surface. Its use can be extended to other blood contacting devices (e.g....
Published: 11/8/2018
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Inventor(s): Matthew Kipper, Ketul Popat, Melissa Reynolds
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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HeX-Bond for molecular engineering, medicinal chemistry applications, materials chemistry, and biological or chemical engineering
Investigators at Colorado State University have discovered a new form of a non-covalent interaction, which is named a hydrogen bond enhanced halogen bond (or HeX-B, for short). The HeX-B was engineered into the enzyme lysozyme to increase the thermal stability of a commonly used enzyme by 1°C and the activity by 15% at elevated temperatures relative...
Published: 11/8/2018
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Inventor(s): Pui Shing Ho, Anna-Carin Carlsson, Matthew Scholfield, Melissa Ford, Rhianon Rowe, Austin Alexander, Ryan Mehl
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Slotted Waveguide Array RF Coil for Ultra-High-Field MRI
Slotted Waveguide Array RF Coil for Ultra-High-Field MRIProblem to be Solved:Current magnetic resonance imaging (MRI) technology utilizes a relatively low static magnetic field (B0 ≤ 3T). Ultra-high field (B0 ≥ 7) imagers increase sensitivity and functionality of MRI overall, but come with their own set of challenges. At higher magnetic fields,...
Published: 11/8/2018
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Inventor(s): Branislav Notaros, Milan Ilic
Keywords(s):
Category(s): Electronic Devices & Instrumentation, Communications & Signal Processing, Human Health, Other Innovations
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Industrial Hygiene Personal Sampling Belt
Industrial hygiene, also known as occupational hygiene, involves the anticipation, recognition, evaluation, control and prevention of hazards from work activities that may result in injury, illness, or otherwise affect the well being of workers. Industrial hygiene is thus both preventative and occupational in nature, being that the focus is on preventing...
Published: 11/8/2018
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Inventor(s): William Brazile, Mollie Brazile
Keywords(s):
Category(s): Human Health, Electronic Devices & Instrumentation, Other Innovations
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Bio-Inspired Siloxane Materials for Ocular Applications
It is estimated that there are over 30 million contact lens wearers in the United States.
In addition to vision correction, a contact lens should:
Maintain stable, continuous tear film for clear vision
Resist deposition of tear film components
Sustain normal hydration
Permeable to oxygen enabling corneal metabolism
Permeable to ions to maintain...
Published: 11/8/2018
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Inventor(s): Susan James, Travis Bailey, Ketul Popat
Keywords(s):
Category(s): Human Health
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Methods for Coating Bone Allografts with Periosteum-Mimetic Tissue Engineering Scaffolds
The inability of bone to heal large defects necessitates the use of bone grafts in many traumatic injuries and disease states. Autograft bone exhibits superior healing over other options due to its inherent ability to provide an osteoconductive scaffold, osteoinductive growth factors, and autogenous osteogenic cells. Unfortunately, limited donor site...
Published: 11/8/2018
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Inventor(s): Matthew Kipper, Nicole Ehrhart, Raimundo Romero, Timothy Gonzales
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Sensors and assays for unconjugated ubiquitin or ubiquitin-like proteins
Intracellular pools of unconjugated ubiquitin must be regulated for the proper functions of virtually all ubiquitin-dependent signaling pathways. To date, however, only a few methods to measure unconjugated ubiquitin have been described. Typically, these methods have low precision or are difficult to implement, and none are amenable to real-time assays...
Published: 11/8/2018
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Inventor(s): Robert Cohen, Yun-Seok Choi
Keywords(s):
Category(s): Biotechnology, Chemicals & Materials, Human Health
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Biocompatible Coatings for Heart Valves and Vascular Grafts
There are currently 300,000 heart valve replacements each year worldwide and this number is estimated to triple by 20501. The materials most often utilized for these replacement valves can have substantial drawbacks for patient health. Bioprosthetic heart valves have shorter functional lifespans when compared to non-biological mechanical heart valves...
Published: 11/8/2018
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Inventor(s): Susan James, Harold Dean IV, Lakshmi Prasad Dasi, Marcio Forleo
Keywords(s):
Category(s): Human Health
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